Dr. Clark Y. Chang

Dr. Clark Y. Chang is the Director of Clinical Services at TLC Laser Eye Centers. He also serves as Director of Specialty Contact Lenses in the Cornea Service of Wills Eye Hospital in Philadelphia, Pennsylvania.

A prominent eye care leader and clinical expert, Dr. Chang is both a published author and sought-after keynote lecturer nationally and internationally. He is also host to the popular ophthalmic technology podcast – “Chang Reaction”.

Education and Professional Focuses:

After finishing his optometry residency training in Primary Care and Ocular Disease, Dr. Chang further completed his clinical fellowship in Cornea and Specialty Contact Lenses under the mentorships of Peter S. Hersh MD and Donald Hersh OD. He also received a Master of Science degree in Low Vision Rehabilitation from Pennsylvania College of Optometry at Salus University.

Dr. Chang’s areas of interests and specialties include laser refractive surgeries and technologies (LASIK, PRK, SMILE, Corneal Inlays, ICL/Implantable Collamer Lens, IOL/Intraocular lens), specialty contact lenses, collagen cross-linking (CXL) and various corneal surgery management.

Publications Include:

  • Expert Comments on “Comparison Between Mix-and-Match Implantation of Bifocal Intraocular Lenses and Bilateral Implantation of Trifocal Intraocular Lenses”
    Extended depth-of-focus IOLs may provide improved visual performance
  • The Use of Hybrid Contact Lenses in Keratoconus and Ectasia Patients Post-Intacs and Collagen Crosslinking
    Keratoconus Causes and Treatment Options
  • Case Reports: The UltraHealth ™ Silicone-Hydrogel Contact Lens for Keratoconus and Irregular Corneas
  • Chang C, Sonsino J. Take the Anxiety Out of Specialty Contact Lens Fitting. Review of Cornea and Contact Lenses, 2018 September: 33-37 Available online at http://www.reviewofcontactlenses.com/article/take-the-anxiety-out-of-specialty-lens-fittings.
  • Chang C. Clinical Corner: Keratoconus Management Tips that I Did Not Learn from My Residency. Fall Newsletter – American Academy of Optometry, Sept: 15. https://www.aaopt.org/docs/publications/newsletters/2018-fall-newsletter-final-web-compressed.pdf?sfvrsn=d54d3676_6.
  • Chang C, DeLoss K. Contact Lenses After Corneal Transplantation. Contact Lens Spectrum, 2018, June: 36-41. Available online at https://www.clspectrum.com/issues/2018/june-2018/contact-lenses-after-corneal-transplantation.
  • Chang C, Rapuano, CJ. Corneal Crosslinking: A First Line Therapy for Keratocoonus. Review of Cornea and Contact Lenses, 2018 May: 30-35. COPE-Approved CE article available online at https://www.reviewsce.com/ce/cxl-a-first-line-therapy.
  • Chang C, Rapuano CJ. Your Top 12 Crosslinking FAQs – Answered. Review of Optometry, 2018 January: 40-45. Available online at https://www.reviewofoptometry.com/article/your-top-12-crosslinking-questionsanswered.
  • Barnett M, Chang C. Considering Scleral Lenses for Astigmatic Patients. Optometry Times. 2017 September. Available online at http://bit.ly/2wboKKE.
  • Chang C, Morgenstern A. The Great Debate in CXL: Epi-On Versus Epi-Off. Advanced Ocular Care. 2017 April:28-29, 32.
  • Chang C, Denaeyer G. Specialty Contact Lenses: Treat Your Keratoconus Patients Right. Review of Cornea and Contact Lenses. 2017 March: 14-17.
  • McKinnis, R, Chang C. A Day in Life of A Keratoconus Patient. Optometry Today. 2016 June; 42(2): 4-9.
  • Chang C. Cornea Cross-Linking: Reshaping Keratoconus Management. Review of Cornea and Contact Lenses. 2016 May: 21-24.
  • Cole J, Chang C (Contributing Author). A Closer Look at Presbyopia Corrections. Review of Optometry, 2016 February: 54-61.
  • Chang C. Corneal Cross-Linking: Past, Present, and Future. Contact Lens Spectrum, 2015 Spetember:30-35, 55.
  • Chang C. Differentiate Your Practice By Treating Keratoconus. Publishes as featured online article (http://www.reviewob.com/differentiate-your-practice-by-treating-keratoconus.aspx).
  • Chang C, Hersh P. Corneal Collagen Cross-linking: A Review of 1-Year Outcomes. Eye Contact Lens. 2014 Nov;40(6):345-52.
  • Eiden SB, Chang C, Davis R, Brafman S. Contact Lens Options for Managing Keratoconus and Keratectasias. Contact Lens Spectrum. 2013 December: 38-44.
  • Chang C. Novel Approaches to Treating Presbyopia. Review of Cornea and Contact Lenses. 2011 Sept: 15-19.
  • Chang,C. Current Non-Surgical Management Concepts for Keratoconus. Published as featured online article (http://treatkeratoconus.com/blog/treatment-options/current-non-surgical-management-options-for-keratoconus/). July 2010

Research Experiences

  • SynergEyes ClearKone Hybrid Lens in the Management of Keratoconus Patients Post Corneal Collagen Crosslinking or in Combination with Intacs (WIRB Protocol 20110233)
  • FreshLook ColorBlends Vibrant Marketing Validation (Protocol P-343-C-002)
  • Interactive, Computer-based, Self-Reported, Visual Function Questionnaire: The Palm Pilot VFQ
  • VED-001 A Randomized Controlled Study of the VederaTM KXS Microwave System with Corneal Collagen Cross-Linking Compared with Corneal Collagen Cross-Linking Alone for Eyes with Keratoconus (WIRB Protocol 20121221)
  • KXL-002 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System with VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes with Keratoconus
  • KXl-005 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System with VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Crosslinking in Eyes with Keratoconus
  • Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia (WIRB Protocol 20111402)
  • Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin (WIRB Protocol 20100790)
  • Safety and Effectiveness of Combined Intracorneal Ring Segments (INTACS) and Corneal Collagen Crosslinking Using the UV-X System for Eyes with Keratoconus and/or Corneal Ectasia (WIRB Protocol 20100447)
  • A 28-week Multicenter, Randomized, Double-masked, Placebo Controlled, Dose-ranging Phase III Study to Assess AIN457 Versus Placebo in Inducing and Maintaining Uveitis Suppression in Adults with Active, Non-infectious, Intermediate, Posterior or Panuveitis Requiring Immunosupression (INSURE Study, Clinical Trial CAIN457C2301and Clinical Trial CAIN457C2302)
  • A prospective Multicenter Clinical Trial to Evaluate the Safety and Effectiveness of the AcuFocusTM Corneal Inlay ACI7000PDT Implanted Intra-Stromally For Modified Monovision in Presbyopic Subjects (Protocol ACU-P08-020)
  • Safety and Effectiveness of UV-X System for Corneal Collagen Cross-Linking in Eyes with Corneal Ectasia after Refractive Surgery (WIRB Protocol 20080044)

Professional Memberships

  • American Academy of Optometry
  • American Association of Optometry
  • OCCRS – Optometric Cornea Cataract and Refractive Society
  • GPLI – Gas Permeable Lens Institute
  • New Jersey Academy of Optometry
  • Pennsylvania Association of Optometry